Large Animal Testing for Medical Devices

Precision Biomarker & Histopathology Analysis for Preclinical & Translational Research

At HT Biosciences, our Biofluids & Tissue Profiling Platform provides comprehensive, GLP-compliant testing services for blood, urine, and tissue samples from experimental animals. Designed for drug developers, medical device innovators, and academic researchers, we deliver reliable, high-throughput data to advance pharmacokinetic studies, toxicity assessments, and disease model validation.

✅ Species Expertise: Mice, rats, rabbits, dogs, pigs, and NHPs.

✅ Global Compliance:

• GLP (OECD/FDA 21 CFR Part 58).
• AAALAC-accredited animal welfare standards.

✅ End-to-End Workflows: From sample collection to regulatory-ready reports.

Core Services

1. Biofluid Analysis

•  Complete Blood Count (CBC): Hematological profiling (RBC, WBC, platelets, hemoglobin).

•  Blood Chemistry Panels:

1. Liver/Kidney Function: ALT, AST, BUN, creatinine.
2. Metabolic Markers: Glucose, lipids, electrolytes.
3. Inflammatory Cytokines: IL-6, TNF-α, CRP (ELISA/Luminex®).

•  Urinalysis: Proteinuria, glucosuria, specific gravity, and NGAL/KIM-1 for renal injury.

2. Tissue & Organ Profiling

•  Histopathology:

1. H&E, Masson’s trichrome, and special staining (e.g., PAS, Oil Red O).
2. Immunohistochemistry (IHC) for protein localization (e.g., PD-L1, amyloid-beta).

•  Organ Function Biomarkers:

1. Cardiac: Troponin I/T, BNP.
2. Neurological: Aβ42, tau, GFAP.
3. Hepatic: Bilirubin, albumin.

•  Toxicopathology: Necropsy, organ weight ratios, and histopathological scoring (e.g., fibrosis, necrosis).

3. Advanced Analytical Services

• LC-MS/MS Metabolomics: Quantification of small molecules, drug metabolites, and biomarkers.
• Flow Cytometry: Immune cell profiling (T/B/NK subsets) in blood/spleen samples.
• Molecular Analysis: qPCR, Western blot, and ELISA for tissue-specific gene/protein expression.

Key Applications